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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MAP2K3
All Species:
18.48
Human Site:
S68
Identified Species:
33.89
UniProt:
P46734
Number Species:
12
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P46734
NP_002747.2
347
39318
S68
A
D
D
L
V
T
I
S
E
L
G
R
G
A
Y
Chimpanzee
Pan troglodytes
Q9XT09
393
43428
S72
D
D
D
F
E
K
I
S
E
L
G
A
G
N
G
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_546666
347
39324
S68
A
D
D
L
V
T
I
S
E
L
G
R
G
A
Y
Cat
Felis silvestris
Mouse
Mus musculus
O09110
347
39278
S68
A
D
D
L
V
T
I
S
E
L
G
R
G
A
Y
Rat
Rattus norvegicus
Q4KSH7
419
47517
G124
I
N
D
L
E
N
L
G
E
M
G
S
G
T
C
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001511595
352
40240
S73
A
D
D
L
V
T
I
S
E
L
G
R
G
A
Y
Chicken
Gallus gallus
Q90891
398
44059
S74
D
D
D
F
E
R
I
S
E
L
G
A
G
N
G
Frog
Xenopus laevis
Q07192
446
50082
G153
A
E
D
L
K
D
L
G
E
I
G
R
G
A
Y
Zebra Danio
Brachydanio rerio
Q9DGE0
361
40575
G84
A
D
D
L
E
Q
I
G
E
L
G
R
G
A
Y
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_477162
334
38176
M63
A
Y
G
I
V
D
K
M
R
H
K
Q
T
D
T
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q20347
363
41178
G70
S
A
N
L
Q
D
L
G
A
I
G
N
G
N
F
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9FJV0
356
39818
K74
A
E
D
L
E
T
V
K
V
I
G
K
G
S
G
Baker's Yeast
Sacchar. cerevisiae
P08018
668
72701
D364
L
D
E
L
E
F
L
D
E
L
G
H
G
N
Y
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
30.7
N.A.
99.1
N.A.
96.5
37.2
N.A.
89.7
30.3
42.1
75.3
N.A.
57
N.A.
37.7
N.A.
Protein Similarity:
100
47
N.A.
99.7
N.A.
98.8
56.7
N.A.
93.1
48.7
58
84.4
N.A.
72.9
N.A.
55.6
N.A.
P-Site Identity:
100
53.3
N.A.
100
N.A.
100
33.3
N.A.
100
53.3
60
80
N.A.
13.3
N.A.
20
N.A.
P-Site Similarity:
100
53.3
N.A.
100
N.A.
100
53.3
N.A.
100
53.3
80
80
N.A.
26.6
N.A.
53.3
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
33.7
23.6
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
52.2
35.6
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
40
46.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
73.3
60
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
62
8
0
0
0
0
0
0
8
0
0
16
0
47
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
8
% C
% Asp:
16
62
77
0
0
24
0
8
0
0
0
0
0
8
0
% D
% Glu:
0
16
8
0
47
0
0
0
77
0
0
0
0
0
0
% E
% Phe:
0
0
0
16
0
8
0
0
0
0
0
0
0
0
8
% F
% Gly:
0
0
8
0
0
0
0
31
0
0
93
0
93
0
24
% G
% His:
0
0
0
0
0
0
0
0
0
8
0
8
0
0
0
% H
% Ile:
8
0
0
8
0
0
54
0
0
24
0
0
0
0
0
% I
% Lys:
0
0
0
0
8
8
8
8
0
0
8
8
0
0
0
% K
% Leu:
8
0
0
77
0
0
31
0
0
62
0
0
0
0
0
% L
% Met:
0
0
0
0
0
0
0
8
0
8
0
0
0
0
0
% M
% Asn:
0
8
8
0
0
8
0
0
0
0
0
8
0
31
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
8
8
0
0
0
0
0
8
0
0
0
% Q
% Arg:
0
0
0
0
0
8
0
0
8
0
0
47
0
0
0
% R
% Ser:
8
0
0
0
0
0
0
47
0
0
0
8
0
8
0
% S
% Thr:
0
0
0
0
0
39
0
0
0
0
0
0
8
8
8
% T
% Val:
0
0
0
0
39
0
8
0
8
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
8
0
0
0
0
0
0
0
0
0
0
0
0
54
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _